How would I resolve the issue seen in the attached screen shot? I have checked masters and all is fine, I have opened on diff computers with diff. graphics cards among many other tests. I cannot narrow in on 1 thing that is causing this because it happens so randomly.
This looks like a multi-page layout. Multi-page layouts are new in ArchiCAD 12, although they are only available for schedules and drawing indexes. (Your drawing looks neither of those...) Multi-page layouts have a different Navigator icon. You can control the multi-page behavior through the "Split Drawing among Multiple Layouts" checkbox, which is on the "Frame" Panel of Drawing Tool Settings. It would be interesting to see the status of that checkbox.
I don't have access to that box for any of my drawings. None fo them, including my schedule/index are large enough to span multiple layouts.
To enusre that function worked properly, I changed the size of the layouts and now with my schedule I have access to that box because the schedule is larger then the sheet but I don't have access to it for my view drawings that are larger then the sheet. To your point, i shouldn't but it was worth double checking. What next?