I doubt EDS or any other architectural software package will accurately simulate coupled CFDs
You are now entering the domain of environmental engineering and multiphysics
First try tidying up and simplifying the geometry,materials,boundaries,etc,etc
Then try exporting to ansys,adina,comsol,etc
You might want to also consider the effects of CFD & Contaminant flow, internal pressures,stress/strain, vibration, acoustics,power generation,corrosion, erosion,PDEs, etc..(the sky is the only limit/boundary)
IMO clients love non stationary & time dependant simulations.