I don't know of any such specific setting.
The closest thing is Snap Guides. When you input the first point of an element, as you move your cursor, horizontal and vertical Snap Guides appear when you cursor is close enough to the horizontal/vertical direction. If you then click, the next point will be constrained to the horizontal/vertical direction without you having to press SHIFT.
In the Work Environment Dialog's Input Constraints and Guides page, the "Cursor Snap Range" field control how close you have to move your cursor. To make this more accurate, you might want to use a higher value than the default 5. The highest possible value is 9 pixels.
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