If you are asking about Publisher Sets, you can set the destination by right clicking on the Set Title Header and it will open a dialogue which has a place to set a default path for save location. If you are asking about saving individual PDF's then no you can't.
"The simplification of anything is always sensational" GKC
AC 25-4013 USA, CadImage Tools
2019 MacBook Pro 16" w/ AMD Radeon Pro 5600M GPU
OS X 11.6
2.4 Ghz 8 core i9, 64 GB RAM
27" LG 5K Monitor