Personally I find pen sets to be a complete waste of time. If you only have two you are lucky. I only have one I use but AC gets upset if I delete all the others. If you have a rigid way of working and perfectly organised templates then they may work. With the addition of Graphic Overrides I quickly realised there were faster ways to present the final output I needed. Going back to proven olde skoole drawing & presentation styles, GO's can be effectively used to create faded underlays & bold or coloured highlights without having to work through each pen set to modify the weights & colours for various layouts and making sure they are correctly cross referenced with each element.
My pen set layout scheme comprises pens 1-8 set for compatibility with legacy cad pens. The lines of duplicate colours are set for pen weight based on old standards from 0.18mm to 2.0mm. In reality I rarely use more than 4 of those weights. The rest of the colours are pastels & grey scales for shading & backgrounds.
I'm not saying GO's are the best way, they work for me and save me hours cleaning up legacy projects where elements & pens have become messed up.
Apple iMac Intel i9 / macOS Sonoma / AC27UKI (most recent builds.. if they work)