Note: This error is fixed in ARCHICAD 22 Update Build 6021.
At Design > Energy Evaluation > Operation Profiles the values of Human heat gain, Service hot water load and Humidity load associated to each Operation Profile don't change with when you use the up and down arrow keys to select one of the Operation Profiles in the list on the top of the dialog. The changing of the values should reflect the change in the selection. If you select the Operation Profiles using the mouse, the values do change. This means that the selection does not work if the arrow keys are used. This also means that if you change any of the values of Human heat gain, Service hot water load and Humidity load, you will change the originally selected Operation Profile and not the one you selected using the arrow keys.
This phenomenon is caused by a bug.
Use the mouse to select the Operation Profile in the list. Avoid using the arrow keys for selection.
The solution is provided in ARCHICAD 22 Update Build 6021. Download and install the update.