I was forced to switch to an Intuos because of some weird joint strain I developed.
I did this to force myself to extend my arm movements, as opposed to a mouse, and it definitely helped. Oh, and it's the largest Intuos model.
It's more work vs. a good multi-button mouse. I spent more than a week nailing down the settings for a dual-monitor setup, but it's never going to be as fast as a mouse in ArchiCAD.
The most annoying part of it is having to "park" the pen each time you need both hands to type. You can't just drop the pen on the tablet. Zooming is also challenging, I resorted to enabling limited touch gestures which I can do while holding the pen. Sometimes I zoom with left hand using the touch wheel.
PM me if you'd like more detail.