As a woodsy traditional residential person I probably should stay out of it, but I did have a glass box to do recently.
Rather than cutting holes (glazing) in a thick (mullions) wall, I used one big wall for the glazing and ran beams and columns though it for the mullions. (This is in 10, so I used multistory walls and columns.) The beams and columns cut the wall naturally. I found I preferred moving the 'bars' around in 3D, rather than stretching a lot of holes. For the doors I used the plainest door I could make, placed directly in the glass wall.
Or, I don't know what I'm talking about.