Hi Barkeater,
As far as I know there are no shortcut profiles set up for left handers but you can build your own in Work Environment - Keyboard Shortcuts under the Options Menu. I think it would be the preferred way to do this for a new user as you will see some of the options available. You can probably even map some commands to ArchiCad that you are used to coming from Vectorworks which may make your transition easier.
There is a free template with shortcuts available from Jared Banks on the Shoegnome site.
http://www.shoegnome.com/template/ if you want to have a look but I don't think they are for lefties.
As a new user you should set up a profile showing your platform and version of Archicad you are using for future questions as answers may be different.
Cheers,
Gerald Hoffman
“The simplification of anything is always sensational” GKC
Archicad 4.55 - 27-6000 USA
2019 MacBook Pro-macOS 15.0 (64GB w/ AMD Radeon Pro 5600M GPU)