Yes, this is possible.
Have a look at the code below. It's not that hard, once one understands that there are some shenanigans to come over (resulting from the use of heavily custom classes and types on the Python package side).
from archicad import ACConnection
conn = ACConnection.connect()
assert conn
acc = conn.commands
act = conn.types
acu = conn.utilities
# get all zones, assign to `elements`
elements = acc.GetElementsByType('Zone')
# prop now holds the GUID of the requested property
prop = acu.GetBuiltInPropertyId('Zone_ZoneName')
# returns a list of all the property values of the elements in question
propval_list = acc.GetPropertyValuesOfElements(elements, [prop])
# replace all occurrences of the first string with the second one
# (this is just a very basic example, of course you could do
# much more sophisticated versions)
zonename_to_replace = "Wohnen"
zonename_new = "Main Room"
for i, elem in enumerate(elements):
# propstr holds the actual string of the current zone name
propstr = propval_list.propertyValues[0].propertyValue.value
# check if we got a match
if propstr == zonename_to_replace:
# if so, construct a new prop value
new_val = act.ElementPropertyValue(
elem.elementId, prop, act.NormalStringPropertyValue(zonename_new))
# set the zone name
acc.SetPropertyValuesOfElements([new_val])
