Have a look in your Work Environment > Mouse Constraints and Methods.
Try turning off the Horizontal-Vertical lock.
And make sure Horizontal-Vertical to Rotated grid is on.
Barry.
One of the forum moderators.
Versions 6.5 to 27
i7-10700 @ 2.9Ghz, 32GB ram, GeForce RTX 2060 (6GB), Windows 10
Lenovo Thinkpad - i7-1270P 2.20 GHz, 32GB RAM, Nvidia T550, Windows 11