Actually, you do not want to change your entire WE when you switch between two and one monitor - only the Palette Layout Scheme. You want everything else - your menus, shortcuts, etc to stay the same.
While on your two monitor set-up, rearrange everything as you would like to see it on a single monitor. In WE > Palette Schemes "Store As" with a new name.
In the Command Layout Scheme > Menus, define a new submenu of the Windows menu (for example) and drag into it the list called "List of Palette Layouts" (screenshot).
This gives you quick access to switching your screen layout - see the next post/screenshot.
Cheers,
Karl
One of the forum moderators
AC 28 USA and earlier • macOS Sonoma 14.7.1, MacBook Pro M2 Max 12CPU/30GPU cores, 32GB