mate, it depends how is your TW file structured..
1. do you have external dwg linked or x-refed?
2. do you use hotlinks or modules?
3. how big is your file?
4. server / network status?
The major slowdown could be caused by messy hotlinks (especially consultant dwgs with a lot of 2D rubbish in them). Personally I try to avoid hotlinks and any repetitive structures are addressed by publishing to modules. Also, try to keep the number of attributes as low as possible (typical example is having zillions of materials that have not ever been used). I use built-in markers / drawing titles in AC11 (quite consolidated) so the internal interpreter does not have to go through customised lib parts (in case you have a lot of details with referenced markers).
So after all try to make everything as simple as you can and personally I would recommend AC11 TW over AC10. as I know AC 11 has a better hotlinking routines and TW is behaving slightly faster (at least for me).
::rk