There are multiple options:
1. For every Drawing placed on a Layout, you can select the Drawing, go to its Settings Dialog and choose "Black and White" in its "Colors" field on its "Properties" panel.
2. Alternately, you can define a Black and White Pen Set and switch to that in the Pen Set field in the same panel of the same Dialog.
3. You can select the PDF item in Publisher Sets click the "Document Options" button and select "Black and White" in the "Save PDF As" field.
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