Hi, thank you for all the advice! Its a standard USB mac mouse - the transparent type, not bluetooth.
I'm trying out all the recommendations:
Trying a standard genius USB mouse appears to work on my machine without a problem, but using my mouse on another mac - no problem.
The problem now appears in other software as well, not just AC & Plotmaker.
On recommendations of the local apple guy, I re-installed OSX and AC, testing in-between installing the updates both for OSX and AC. Same result both times.
I just don't know where to look next..
I suspect the best course of action is to ditch the mac mouse..
If I was working on pc, I would suspect a virus.
AC 6, through 27
iMac 27' 3,1 GHz 6-Core Intel Core i5
500GB OS X12.7.3 Monterey