With parametric profiles being introduced in ARCHICAD 22, came new attributes to manage, the offset modifiers. With the help of the Modifiers, you can create more intelligent Profiles for Walls, Beams, and Columns, by defining the edges parametrically in the Profile Editor. This will allow offset or control of individual (or multiple) edges, at the instance level, either graphically or via element settings.
Managing them is simple, but it's good to understand some pointers that can help us on the way: