You should setup layercombinations for your layout, yes.
I would assume there is a standard for layer names / numbers where you work. We have one for building elements (numbers + names), added to that we have layers for grid markers, sections, elevatations, worksheets, details, SEOs, annotation for different scales, 2D info for different scales, different type of zones, 2D and 3D visualisation additions and 1 layer for 'help' items you want hidden at all times.
As a guideline here is a list of (some of) the layercombinations we use in our template (which is largely based on the NL sub template):
All Layers
Fire safety plans
Gross Area plans
Structural
Details
Sections (1:20/1:50/1:100)
MEP
Foundations
Function Zoning
Elevations (Preliminary Design/Contract Documentation)
IFC exports (structural/architectural/etc etc)
Furniture / Fittings
Create Objects
Ceiling
Floorplan (1:20/1:50/1:100/1:200)
Stairs
Visualisation
Erwin Edel, Project Lead, Leloup Architecten
www.leloup.nlArchiCAD 9-26NED FULL
Windows 10 Pro
Adobe Design Premium CS5