I see ejrolon has beat me to the punch with a concise answer. I will post anyway with a graphic included...
The magic wand tool is what you want to use. All steps below are done in 2D plan view.
1. Assuming you already have the primary slab drawn.
2. Draw a curved slab, or closed polyline representing the subtraction desired.
3. Now select the primary slab, it should turn a shade of green.
4. To use the magic wand, make sure of two things:
A. The slab tool is the current default tool palette
B. the magic wand tool is active.
5. With this setup, use the space bar while the magic wand is hovering over your curved slab, and hit the space bar. You will see the resulting removal of the curved shape.
6. Finally, remember to also erase the curved slab you drew in step 2. In plan view you won't see it, but in 3D you will discover it is still there. So delete it.
You could also have drawn a closed spline shape, as the curved shape for the subtraction. The key is that at the moment you use the magic wand and the space-bar, the slab tool must be the default tool in the Tool Box.
Whichever method you use you will have to delete the left over shape inside the hole you cut in the slab. You can also use this method to cut away edges, not just holes.
Here is a 3D image showing the results of both methods.