I don't notice any, not compared to the advantages. I like highly developed composites. I like the way the finished drawings read and print, and attaching property scripts to them. So, I'll have one for siding I'll offset 1.25", and one for stucco I offset 1.5 inches. It keeps the stud where it needs to be... over the edge of the floor framing. So, whatever wall composite I need will align properly with the framing. I do have the composites linked to property objects, so that's a great reason to develop accurate composites.
Since I do reuse my plans for many years, over and over, my only regret has been laziness to properly set things up earlier on. But, at this point I am pretty well standardize and everything integrates well. I do think the more true to life you model the better off you are in the long run. If you'll never open a project again to extract info, then it probably doesn't manner at all, but I do daily, so to offset a reference line for true framing based modeling is worth the little extra effort. And, with favorites it's pretty automatic to key in your main assemblies.
I only offset to the framing component (stud or block). If I use a stucco/block composite I offset the composite to the block, or 1.5". The walls above align appropriately to the framing.
