In my experience when TW behaves like that it sometimes is because you need to do a send and receive. Also it might be that one of the items affected by editing the profile is not reserved.
As a test try creating a new profile and see if you can edit that.
Eduardo Rolón AIA NCARB AC27 US/INT -> AC08
Macbook Pro M1 Max 64GB ram, OS X 10.XX latest another Moderator
Yes i can create another profile, that's actually how i've been getting around this quirk.
Sending/Receiving doesn't free it up either.
I also 'reserved all' too, just to test that out.
Having similar issues with 'layer combination'--in that, it's 'editable', and i can change it, but when i send/recieve, if reverts back to previous value.