I've worked on about 5 or so projects on AC10, and have not had this happen (until now!)
Bit of a mystery, as the project origin is in the corner of the building and the origin in the layout is in the corner of the sheet also.
The job is small residential, with no crazy neighbourhood plans or other factors which could effect it.
I tried changing the view to "zoomed area", "current zoom' and "none", and it made no effect
I noticed it was placing it in the same spot, so i tried dragging in the drawing to some hotspots i randomly placed on the layout, and, as you can see it placed it the same distance (x and y) from each.
I then measured this distance and then looked in the model around the equivalent place (in the opposite direction) on each story... and can confirm that there was nothing there, but that was a long shot anyway.
I exhausted my thoughts, maybe someone can shed light...